What Is The Entourage Effect?

When you consume cannabis, you are ingesting hundreds of compounds that work together to maximize therapeutic benefits. Think of cannabis as a team, we have the team captains CBD and THC, but in order to win the game you have to have the rest of the team in their own supporting roles working together and adjusting to whose on the field to score the most points. Each compound, even the smallest one, comes with its own unique qualities and effects on the body. To produce the greatest effects and minimize negative effects the compounds work together as a team. Although cannabinoids can be beneficial separately, cannabis clinicians often recommend combining cannabinoids due to the entourage effect. 

With this botanical mechanism in mind, CKSoul’s formulas are designed to have full spectrum cannabinoid profiles with all natural terpenes in order to maintain the most therapeutic properties of the plant. Here we will break down how the entourage effect works with different compounds of whole plant cannabis. 

Main Cannabinoids

THC and CBD are the most researched cannabinoids in regards to the entourage effect. Researchers are just beginning to understand the way that these main cannabinoids work synergistically to produce the most therapeutic effects. THC is the most abundant cannabinoid that produces the psychoactive effect while CBD is the second most abundant known for its anti-inflammatory and anti-anxiety properties. Studies have shown, due to the entourage effect, a combination of CBD and THC may have the ability to enhance therapeutic benefits such as:

  • Decreased negative experiences from THC- Psychoactivity, “couch lock”, paranoia, and temporary memory loss
  • Potentially produces more anti-tumor effects 
  • More successful in conjunction when used by cancer patients 
  • Potentially amplifying analgesic (pain relief) properties  


Cannabis is far more than the popular cannabinoids: CBD and THC. There are over 100 phytocannabinoids that are unique to the cannabis plant that all interact with the endocannabinoid system, and in turn promote balance within the bod  Some of the more recognizable phytocannabinoids such as CBDa, THCa, CBN, CBG, CBC, THCV, have a wide range of potential medical and therapeutic benefits. Cooperatively these phytocannabinoids work together instead of one leading the team for more potential benefits and enhancement of desirable effects that are just being discovered. 


Terpenes are responsible for the array of aromas and flavors present in cannabis strains. Other than providing us with the enjoyable smells and tastes, terpenes are also responsible for the potential enhancement of the therapeutic properties of the other compounds of cannabis. Like cannabinoids and phytocannabinoids, terpenes have the ability to bind with the cells in our body and affect our cannabis experience. Terpenes, like cannabinoids, are beginning to be recognized as a very important piece to unlock the potential benefits of cannabis. Terpenes play their role in the entourage effect by interacting with how cannabinoids bind to receptors (CB1 and CB2) and their potential to increase the permeability in the body to these cannabinoids, which would in turn increase the potential benefits. Terpenes are not commonly ingested alone, but are either naturally occurring or reintroduced to cannabis products  such as CKSoul's tinctures to maintain the synergistic benefits of the whole plant. 

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